Dobutamine hydrochloride is chemically designated as 423phydroxyphenyl1methylpropylaminoethylpyrocatechol hydrochloride. For solution and drug compatibility information, see compatibility under stability. Bactrim, cancidas, cellcept, cymevene, lasix, solumedrol, tazobac reserve drugs. By continuing to browse this site you are agreeing to our use of cookies. Decreases preload and afterload bya direct dilating effect on vascular smooth. On rare occasions, infusion rates up to 40 mcgkgminute iv have been required to obtain the desired clinical response. Twice weekly, iv dobutamine infusion up to 5mcgkgmin infusion, for the duration of 6 months. Critical care intravenous drug administration guide. Some patients are on both dobutamine and milrinone. Patients are taught to maintain their ambulatory infusion pumps, taught how to use their back up pumps, understand emergency procedures related to pump malfunction. Though vastly different, these tools share a basic truth.
Dobutamine concentrate for intravenous infusion should be diluted before use. Correct hypovolemia with volume expanders before initiating dobutamine therapy. Since it does not act on dopamine receptors to inhibit the release of norepinephrine another. Im making up some reference cards for commonly used drugs in our icu. Routine electrolyte and renal function testing will be performed and electrolytes corrected as indicated.
Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. Intravenous infusions of nitroprusside, dobutamine, and. Dobutamine may also be used for purposes not listed in this medication guide. Find information on dobutamine dobutrex in daviss drug guide including dosage, side effects, interactions. If severe or symptomatic, intravenous pressers drugs that mimic adrenaline andor temporary pacing is needed. Dobutamine hydrochloride dosage and administration administration.
Apr 05, 2009 dobutamine is a synthetic catecholamine that is generally considered the inotropic drug of choice for the acute management of severe systolic heart failure. Dogs were given continuous intravenous infusion of dobutamine in 5%. It takes spikes, syringes, and pumps to make an intravenous iv solution. Iv doses should be expressed in milligrams not ampules, concentration or volume. Dobutamine is indicated for patients who require a positive inotropic support in the.
Thames valley ysite intravenous drugs compatibility chart. Dilute 250 mg in 250 ml of compatible solution to yield final. Dobutamine hydrochloride in 5% dextrose dobutamine. Intravenous compatibility chart free html5 flip book. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for this dosing guide is obtained. Dobutamine is a directacting agent whose primary activity results from stimulation of the. Lists drug compatibility and stability in small volume and large volume parenteral solutions. Milrinone and dobutamine were compared in 15 patients with new york heart association functional class iii and iv congestive heart failure. Onset of action occurs within 2 minutes, although peak pharmacodynamic activity can be delayed up to 10 minutes. Home explore intravenous compatibility chart drug information for the.
Administration to patients as an intravenous infusion see instructions. Dobutamine 5 mgml, solution for infusion summary of. Dailymed dobutamine hydrochloride in dextrose dobutamine. At the time of administration, dobutamine injection must be further diluted in an iv container. All information is intended for use only by competent healthcare and safety professionals and should be utilized in conjunction with pertinent clinical or situational data. Dilute 20 ml of dobutamine in at least 50 ml of diluent and dilute 40 ml of dobutamine in at least 100 ml of diluent. It is primarily a b1receptor agonist cardiac stimulation, but it also has mild b2 effects vasodilation. Providing the most uptodate, complete and innovative injectable drug compatibility and stability information in hospital pharmacy worldwide, the king guide is a proven, authoritative resource for pharmacists, nurses, physicians and other practitioners involved in the preparation and administration of intravenous drugs. Trissels in iv compatibility micromedex from the site homepage, select the iv compatibility tab. Ysite injection drug compatibility chart for critical care wards a m io d a ro n e a. The original standard in hospital pharmacy since 1971. Prior to administration, have second practitioner independently check. Iv vasoactive medications are potentially dangerous.
Intravenous compatibility chart acyclovir acyclovir. Iv compatibility in critical situations june 7, 2018 by pharmacy joe leave a comment in this episode, ill discuss iv compatibility in critical situations. Dobutamine fda prescribing information, side effects and. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. At the time of administration, dobutamine must be further diluted in an iv container to at least a 50 ml solution using one of the following intravenous solutions as a diluent.
Add 250mg of dobutamine 20ml to 80ml of compatible iv fluid i. Outcome and safety of intermittent dobutamine infusion at a. Compatibility is denoted by an icon and simple description. Dobutamine may also be used for purposes not listed in this medication. Administered by a nurse with neonatal iv drug certification. Dilute 30 mgkg body weight to a final volume of 50 ml of infusion fluid.
All patients underwent hemodynamic evaluation to confirm a beneficial response to low dose 5 microgramskg. Dobutamine is administered via continuous iv infusion. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for. Iv compatibility question general nursing allnurses. May be given direct iv or further diluted in 50ml nsd5w. Easy, intuitive access within the lexicomp app helps improve workflow efficiencies.
Iv geriatric patients, debilitated patients, or asa iiiiv patients. Iv ozone, high dose vitamin c booklet index page no. Doctors give trusted answers on uses, effects, sideeffects, and cautions. Dobutamine intravenous infusion is incompatible with bicarbonate and other. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Ysite injection drug compatibility chart for critical care wards key to symbols.
Only drug dose rate, fluid administration rate, and fluid bag size determine amount of drug added to iv bag. While acute positive inotropicvasopressor support e. Dobutamine in 5% dextrose injection, usp flexible plastic. Feb 02, 2018 the clinical formulation is supplied in a sterile form for intravenous use only. It does not cause the release of endogenous norepinephrine, as does dopamine.
Clinical experience with dobutamine following myocardial. Do not administer solutions containing dextrose through the same administration set as blood. Dobutamine hydrochloride monograph for professionals. Dobutamine in 5% dextrose injection, usp is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for injection. The majority of sources cited define compatibility by physical compatibility rather than chemical compatibility this table is a guide only. Nov 09, 2018 dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better.
Dobutamine hydrochloride in 5% dextrose injection is a sterile, nonpyrogenic solution of dobutamine hydrochloride, usp and dextrose, usp in water for injection, usp. Ectopic heartbeats, increased heart rate, elevations in bp, hypotension, phlebitis, local inflammatory changes. Dobutamine is a synthetic catecholamine that displays a strong affinity for the. Dobutamine is usually given after other heart medicines have been tried without success. Use one of the following intravenous solutions as a diluent. Common and rare side effects for dobutamine intravenous. Side effects include shortness of breath, nausea, fever, headache, and increased blood pressure. Normal saline glucose and sodium chloride 5% dextrose 10% dextrose hartmanns store at room temperature protect from light. Dobutamine hydrochloride is chemically designated as 423phydroxyphenyl1 methylpropylaminoethylpyrocatechol hydrochloride. Presents separate listings of data for drugs given via ysite, syringe, and admixture. Iv geriatric patients, debilitated patients, or asa iii iv patients.
We added new compatibility information for calcium chloride, epinephrine hydrochloride, conivaptan, dobutamine hydrochloride, dopamine hydrochloride, esmolol hydrochloride, furosemide, heparin sodium, total parenteral nutrition solutions with 46 drugs, and alprostadil with drugs. Im referring to a drug book for compatibilities with other iv solutions. Use one of the following intravenous solutions as a. Your breathing, blood pressure, oxygen levels, and other vital. Dobutamine injection dobutrex brand is no longer available in the us is a prescription heart disease drug.
Iv drug compatibility chart a alteplase activase, rtpa amiodarone cordarone argatroban atropine calcium chloride diltiazem cardizem dobutamine dobutrex dopamine epinephrine adrenalin esmolol brevibloc furosemide lasix heparin insulin regular lidocaine xylocaine lorazepam ativan magnesium sulfate. Dobutamine must always be administered via a dedicated lumen, and never piggybacked with other drugs or fluids. Colucci ws, wright rf, jaski be, fifer ma, braunwald e. Top 21 on dobutamine antidote healthtap healthtap healthtap.
Outpatient dobutamine for endstage congestive heart failure. Dobutamine is a directacting inotropic agent whose primary activity. Dec 19, 2018 dobutamine intravenous infusion is incompatible with bicarbonate and other strong alkaline solutions. Dobutamine 5 mgml, solution for infusion summary of product. Administered by iv infusion only, resulting in complete bioavailability.
Medscape indicationspecific dosing for dobutamine, frequencybased adverse. Have second practitioner independently check original order, dosage calculations, and infusion pump settings. Provides a database that cites results from 3,000 references in the. Selected from data included with permission and ed by first databank, inc. Dobutamine dobutrex daviss drug guide nursing central. Dopamine, dobutamine drug cards flashcards quizlet. Levetiracetam is an anticonvulsant for partial, myoclonic, and primary generalized tonicclonic seizures. The first iv medication guide iv push medications recommended guidelines lists medications that can be safely pushed or directly injected into a vascular access device vad or iv or through the proximal injection port of an administration set of a compatible, continuous iv infusion in a. Full information can be obtained from your pharmacy department key references adrenaline 18 1 compatible reference 1 1 handbook of injectable drugs lawrence trissel available on. Medication will be administered under medical supervision and continues ecg and vital sign monitoring. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. Dobutamine is used shortterm to treat cardiac decompensation due to weakened heart muscle. The clinical formulation is supplied in a sterile form for intravenous use only.
Read this lesson to learn how it works, which scenarios it would be used in, and what the possible side effects might be. Intravenous infusion of dobutamine is also possible after dilution with compatible infusion solutions such as. Dobutamine infusions must be administered by syringe pump or infusion pump. Also has been administered by intraosseous io infusion in the setting of acls. The recipient will receive more details and instructions to access this offer. Dobutamine side effects, dosage, interactions drugs. Mar 20, 2015 preventive strategies always check for compatibility standardize protocol for drug preparation check for alternative modes of administration separation of drug doses by time and place usage of multilumen catheters use inline filters 18. Must dilute dobutamine hydrochloride concentrate for injection with a compatible iv solution prior to administration dilute 20 ml of concentrate in at least 50 ml of diluent and 40 ml of concentrate in at least 100 ml of diluent. Standard ivlines in pvc connecting lines for syrines in pe adsorption to inline filter ex. Evidence defining compatibility of levetiracetam with cardiovascular agents is needed for patient safety. Dobutamine injection usp dobutamine hydrochloride is a. Normal salineglucose and sodium chloride5% dextrose. Dobutamine hydrochloride is a directacting inotropic agent whose primary activity results from stimulation of the. Provides stability and compatibility data using 11 different infusion fluids.
If storage instructions are observed see also section 6. Physical compatibility of levetiracetam injection with. Nurses make 23 visits weekly depending on the current clinical status. Learn about drug interactions between dobutamine iv and furosemide inj and use the rxlist drug interaction checker to check drug combinations. Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible. Results supported by more than 4,700 unique references. Each 20ml vial contains 250mg of dobutamine add 250mg of dobutamine 20ml to 80ml of compatible iv fluid i. For intravenous infusion, give continuously in glucose 5% or sodium chloride 0.
Where multiple infusions are required, it may be acceptable to administer dobutamine with other inotropes, via a threeway tap. Feb 06, 2020 dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Dobutamine has a halflife of 2 minutes, a rapid onset of effect, and steadystate. Dobutamine, sodium bicarbonate calcium gluconate compatible via y site with amikacin, aminophylline. Mar 27, 2019 dobutamine hydrochloride in 5% dextrose injection is a sterile, nonpyrogenic solution of dobutamine hydrochloride, usp and dextrose, usp in water for injection, usp. Each 100 ml contains dobutamine hydrochloride equivalent to 100 mg, 200 mg, or 400 mg of. Information in this booklet should be used as a guide only. For instance, i understand ysite compatibilities as being you can connect your dobutamine infusion into a. Identify these contraindicated and dangerous dobutamine iv dobutrex iv drug combinations to avoid with the rxlist drug interaction checker tool. Trissels 2 clinical pharmaceutics database clinical. Dobutamine dobutamine hydrochloride dose, indications. Intravenous compatibility chart drug information for the. This ed material has been downloaded from a licensed data provider and is not for distribution, except.
720 100 1028 599 1582 930 481 840 447 1344 1523 321 710 538 972 48 443 1586 1431 1595 1453 34 1242 1014 187 1196 1241 1270 1456 688 896 836